Characteristics of endometrial receptivity in women with different endometrial thickness

Aim: to evaluate the expression of estrogen (ER) and progesterone (PR) receptors in endometrium during "implantation window" women with a history reproductive dysfunction different endometrial thickness. Materials Methods. A prospective single-center cohort comparative study was conducted. The main group included patients hypoplastic (< 7 mm according ultrasound data on preovulatory days) (n = 52), comparison consisted normal thickness 62) (women both groups dysfunctions unclear cause), control 16 healthy fertile women. An aspiration biopsy performed day 6–8 after ovulation simultaneous collection peripheral blood sample measure level estradiol (P). Endometrial biopsies were examined histological immunohistochemical (expression ER, PR) methods. Results. All had an ovulatory cycle, serum ≥ 16.1 nmol/L (6–8 days ovulation) normoestrogenemia. E2/P similar all cohorts (p > 0.05). Indicators PR, 16), found 21 % 11 out 52) 32 20 from groups, respectively. remaining 79 41 "thin" (main group) 68 42 (comparison ER PR indices glands stroma significant differences < 0.05) parameters (excepting stroma) those (control group), but without relevant between these regardless Conclusion. In disorders, problems, noted mm) by 50 less often than uterine mucosa. At same time, is not absolute predictor disorders hormone-receptor characteristics endometrium: every fifth case, magnitude determined.